Recently, Huibang Biotech's "Planned Treatment for Premature Rupture of Membranes" was successfully selected into the fifth batch of health technology promotion projects in Anhui Province.

The Anhui Province Health Appropriate Technology Promotion Project is mainly for county-level public hospitals. Through the promotion and application of appropriate technologies in grassroots medical institutions, it promotes the effective implementation of the hierarchical diagnosis and treatment system, and continuously improves the service capabilities of the existing technical personnel of grassroots medical and health institutions.

  With the improvement of my country's economic level and the improvement of the diagnosis and treatment of critically ill pregnant women, the diagnosis and treatment of premature rupture of membranes and premature delivery are applied in hospitals at all levels in China The degree is uneven, especially in hospitals below the city and county level. For example, grass-roots medical staff are not familiar with clinical guidelines and lack the accuracy of disease diagnosis, which directly leads to a lack of individualized treatment plans, over-reliance on surgery, and inability to effectively follow up on the latest treatment concepts at home and abroad, resulting in premature birth rates and adverse maternal and child outcomes. Too high, and even serious complications. The overall diagnosis and treatment plan has no rules to follow and lacks standardization. On the other hand, patients in large hospitals, such as provincial and municipal tertiary hospitals, are over-concentrated, and the waiting period for hospitalization and surgery is long, which makes patients and their families have poor medical experience and overall satisfaction. The extremely unreasonable distribution of such medical resources needs to be resolved urgently. With the policy support of the medical authorities, the system of hierarchical diagnosis and treatment, medical consortia, and two-way referral has been gradually improved. Only by enabling grassroots medical staff to master and apply such technologies can the problem be fundamentally solved. Promote the standardized diagnosis and treatment of preterm premature rupture of membranes to counties, cities and hospitals as soon as possible by means of out-of-hospital consultation, two-way referral, technical training, and advanced training, so as to benefit the general public and promote the process of deepening medical and health reform . 

"Planned treatment for premature rupture of membranes" is applied to the joint quantitative detection of IGFBP-1 and fFN. By screening IGFBP-1 and fFN, it is expected to improve the accuracy of diagnosis of premature rupture of membranes and avoid premature rupture of membranes. The risk of mother and child caused by untimely treatment of broken water infection can be reduced, and the psychological burden of asymptomatic or suspected pregnant women with broken water can be reduced, and the shortage of medical resources can be alleviated. At the same time, combined with the dynamic monitoring of fFN level, it can predict the delivery time of pregnant women and guide the effect of miscarriage protection or drug induction.

This technology combined quantitative detection of IGFBP-1 and fFN is the first in China. Both indicators are listed as guidelines recommended detection indicators.

Existing similar technologies include single qualitative detection of IGFBP-1, single qualitative or quantitative detection of fFN, and joint qualitative detection of IGFBP-1 and fFN. 

Compared with traditional technology, this technology has the following advantages:

①Operation advantages: It realizes simultaneous detection of two indicators in one sampling, which is not only convenient for doctors to operate, but also improves patient compliance, and this product does not require vaginal speculum, reducing patient pain and sampling risk;

②When the traditional fFN test is positive, it is impossible to determine whether the risk of premature birth is caused by premature rupture of membranes, because it is impossible to determine whether the fFN comes from the chorionic decidual space or the amniotic fluid, and the dual detection can clearly determine whether it is a simple risk of premature birth or premature birth Combined with premature rupture of membranes, it is convenient for doctors to provide targeted treatment to patients, while avoiding disputes between doctors and patients when the test result is positive.

③IGFBP-1 is a marker protein in amniotic fluid, and the measured value of IGFBP-1 is positively correlated with amniotic fluid leakage. The higher the positive value of IGFBP-1, the higher the severity of premature rupture of membranes, indicating a larger amount of amniotic fluid leakage, which is convenient for doctors to refer to. Applicable to: Routine screening for premature rupture of membranes and premature birth risk in pregnant women. 

This promotion project first accurately diagnoses premature rupture of membranes and predicts premature birth, and then intervenes and guides treatment in advance to prevent intrauterine infection, prevent premature birth, and reduce the incidence of premature babies. This technology is economical and practical, can effectively improve the fetal birth rate and the quality of newborns, respond to the national family planning policy of "beautiful birth and childcare", improve the living standards of the people, and reduce the overall medical burden.